I like using the ED at minimum Drive before my MXR+ Series 2000. This gives me two different tonal options for my MXR+ distortion. Without the ED, the distortion is biting, bright, gnarly, perfect for Hell in Bucket. Minglewood; with the ED, the distortion is a tad warmer, a little more compressed, perfect for Loser, Valerie. With my programmable looper, its easy to set up different configurations. I also like using the ED after the Mutron for a little more clipping when needed in Shakedown, Estimated, etc.
I admit I use the ED sparingly.